Supplier:
Alomone Labs Limited.Cat no: C-140
BUY CNQX
This non-NMDA receptor antagonist inhibits [3H]AMPA binding to quisqualate receptors at submicromolar concentrations. CNQX also selectively blocks the excitatory action of quisqualate and kainate on spinal neurons with little or no effect on that of NMDA.
The concentrations that inhibit 50% of [3H]AMPA binding (IC50) for CNQX in dorsal horn neurons is 300 nM.
The association of AMPA receptors with TARP auxiliary subunits converts CNQX from an antagonist to a weak partial agonist. CNQX induces partial domain closure, consistent with the activity of a partial agonist. CNQX blocks both fast AMPA-mediated and slow kainate receptor-mediated mEPSCs.
EC50 values for depression of the monosynaptic ventral root reflex is 1.0.0.3 uM.
Direct binding studies using CNQX as a radioligand show that CNQX binds with high affinity (40 nM) to both high (14 nM) and low (235 nM) affinity AMPA binding sites in rat brain.
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SPECIFICATIONS
Catalog Number
C-140
Size
50 mg
Purity
>98%
Concentration
300 nM - 500 micro M
Shipping Temp
Room Temperature
Molecular Weight
232.2 Da
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