Ca2+ Channel Modulator Explorer Kit.
Voltage-dependent Ca2+ channels (Cav) form an important route for Ca2+ entry into cells, upon deviations from the cells� resting membrane potential. There are ten Cav alpha1 subunit genes, divided into three subfamilies on both a functional and sequence homology basis. The Cav1 subfamily includes four genes which encode the L-type channels, the Cav3 subfamily includes three genes encoding the T-type channels and the Cav2 subfamily consists of three isoforms encoding P/Q- , N- and R-type channels, with all three contributing to neurotransmitter release in neurons.
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