Bombesin is an active neuropeptide originally isolated from amphibian skin but also found in the central and peripheral nervous system of amphibians. Later it was established that mammals and birds express two family groups of endogenous Bombesin-like factors, the gastrin-releasing peptides and neuromedin B2. The biological activities of bombesin are mediated through a family of three specific G-protein coupled receptors (GPCRs): BB1 which is also known as a neuromedin B receptor, BB2 also known as a gastrin-releasing peptide receptor and BB3 which is a low affinity binder for the Bombesin-like factors.
Bombesin and Bombesin-like factors show a broad range of biological activities such as regulation of smooth muscle contraction, stimulation of neuropeptide and hormone secretion, modulation of neural activity, growth regulation, and mediate anorexic effects in the hypothalamus.
GPCR ligands are now part of our growing portfolio of GPCR related products, which also includes antibodies. Alomone Labs is pleased to offer Bombesin (#GPB-100), a biologically active synthetic peptide, in convenient sizes and at attractive prices.
Protein Coupled Receptor Ligands; Bombesin Receptor Ligands.
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