BDS-II. A Specific Blocker of Kv3 Channels. BDS-II is a 43 amino acid peptidyl toxin isolated from the sea anemone Anemonia sulcata venom. BDS-II was shown to be a specific Kv3.4 blocker. BDS-II blocked 70% of the Kv3.4 current in COS-transfected cells at a concentration of 2.8 ??μM. The blocking effect is rapid, direct and reversible. Recently it was shown that it blocks other Kv3 channels with similar potencies. BDS II inhibited the A type K+ current in human pulmonary artery smooth muscle cells In skeletal muscle cell line (C2C12), BDS II inhibited single Kv channel currents and shifted the resting membrane potential in a dose dependent manner and in a similar way it inhibited Kv3.4 channels co-expressed with the KCNE3 auxiliary subunit in CHO cells. The inhibition of these channels was about ten times less potent than the inhibition of Kv3.4 channels expressed alone (IC50 of about 1 ??μM and 10 ??μM respectively).
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