BUY BDS-I

BDS-I. (Blood depressing substance I). A Specific Blocker of K_v3 Channels. BDS-I is a 43 amino acid peptidyl toxin isolated from the sea anemone Anemonia sulcata venom. It is reported to be a selective blocker of K_v3.4 K/^+\ channel. BDS-I blocked 60% of the K_v3.4 current in COS-transfected cells at a concentration of 2.5 ??μM. The blocking effect is rapid, direct and reversible. Recently it was shown that it blocks other K_v3 channels with similar potencies. BDS-I inhibited K_v currents in carotid body cells an effect, which disappeared after chronic hypoxia. Such a result helped establishing the unique role played by K_v3 channels in the response to hypoxia.BDS I (2.5 ??μM) also reduced the native transient K/^+\ current and increased the action potential duration in hippocampal granule neurons. In corneal epithelial cells BDS I (400 nM) inhibited most of the detected K_v current. In magnocellular neurosecretory neurons of the hypothalamus 100 nM BDS I, inhibited about half of the K_v current and increased the action potential duration. In fast spiking neurons from different brain areas, 2 ??μM BDS I inhibited part of the K_v current and broadened the action potential and reduced spike frequency. Ion Channel Modulators; K/^+\ Channel Blockers.