Supplier:
Alomone Labs Limited.Cat no: STA-200
BUY Apamin
Apamin is a natural peptide isolated and purified from Apis mellifera bee venom. Apamin blocks small conductance Ca2+-activated K+ channels (SK). It is specific for the SK1-3 isoforms, but ineffective in blocking other calcium activated K+ channels (see for example). In mammalian cell lines Apamin blocks expressed hSK1 with an IC50 of ~10nM, rSK1 and rSK2 with IC50 of ~3 and <1 nM respectively and liver rSK3 with IC50 <1nM. In Jurkat T-cells 5nM of Apamin blocks 70% of hSK2 currents.
Blocking these channels with Apamin slows down neuronal activity after hyperpolarization (see for example), as well as smooth muscle contraction and catecholamine secretion in adrenal gland. Electrophysiology application of long (~400ms) voltage ramps, covering the whole physiological range (-160 to +40mV), in the whole cell patch-clamp or voltage clamp configurations, before and after bath perfusion of the drug, allows the detection of the blocked channel currents (by comparison)
Alomone Labs is pleased to offer Apamin, a synthetic product in economical sizes at a very attractive price.
Ion Channel Modulators; K+ Channel Blockers.
Prices direct from Alomone Labs Limited.
Quick response times
Exclusive Absave savings/discounts
SPECIFICATIONS
Catalog Number
STA-200
Size
5 x 1 mg
Purity
>98%
Concentration
100 nM - 1 micro M.
Shipping Temp
Room Temperature
Molecular Weight
2028 da
SUPPLIER INFO
Latest promotions
New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...
Buy any polyclonal or monoclonal antibody from our extensive range of pre-made antibodies and for a limited time only receive a $50 discount!(T&C apply:...
We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!
For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...
10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...
Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...
Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...
Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...
Top suppliers
Agrisera AB
11 products
Biotrend
Biosensis
969 products
ABBIOTEC
3011 products
SDIX
1 products
Spring Bioscience
2291 products
Cell Signaling Technology
4976 products
Rockland Immunochemicals, Inc.
7592 products
Boster Immunoleader
1533 products
Proteintech Group
1 products
OriGene Technologies Inc.
5281 products
Maine Biotechnology Services
227 products
BD (Becton, Dickinson and Company)
1 products
ABNOVA CORPORATION
Randox Life Sciences
1502 products
