BUY Amlodipine besylate

Amlodipine besylate. A Potent blocker of L- and T-type Ca_v Channels
L-type (Ca_v1), voltage-gated Ca²⁺ channels are plasma membrane protein complexes which allow the passage of Ca²⁺ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.
Dihydropyridines (DHP) are molecules that acts as allosteric modulators of L-type channels and many are used in the clinic to treat hypertension. Amlodipine besylate is a DHP that acts as a L-type, voltage-gated Ca²⁺ channel blocker and is used in the clinic to treat hypertension. Amlodipine inhibit Ca²⁺ -induced contractions in depolarised rat aorta (IC₅₀ 1.9 nM) but, displayes a very slow onset of action. Contractions induced by depolarising steps with 45 mM K\^+\ are much less potently blocked by amlodipine (IC₅₀ 19.4 nM) and guinea pig papillary muscle single-cell slow action potentials are blocked�at a concentration of 5 μM.
Amlodipine besylate inhibits L- and T-type Ca_v channels with similar potency.
Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers