alpha-Pompilidotoxin. alpha-PMTX. Enhancer of Nav Currents (Slows Inactivation). alpha-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide. alpha-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission. Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons. Effective at concentrations of 10 nM in cultured rat cortical neurons.
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