Supplier:
Alomone Labs Limited.Cat no: A-105
BUY A-803467
The TTX-resistant, Nav1.8 channel is expressed almost exclusively in the PNS and has been shown to mediate most of the well documented TTX-resistant currents of DRG neurons' action potentials. Hyperexcitability, manifested by increased action potential firing and coded information transfer to the CNSпїЅof nociceptive DRG neurons, probably lie on the basis of several pathological pain states. Both genetic and pharmacological evidence suggest that Nav1.8 channel might serve as a target in pain control.
A-803467 is a potent and selective blocker of the TTX-resistant Nav1.8 channels. A-803467 is a state dependent inhibitor of the channel, with IC50 = 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states.
A-803467, was used as a pharmacological tool to demonstrate the expression of Nav1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart.
Ion Channel Modulators; Voltage - Gated Na+ Channel Blockers.
Prices direct from Alomone Labs Limited.
Quick response times
Exclusive Absave savings/discounts
SPECIFICATIONS
Catalog Number
A-105
Size
25 mg
Purity
>99%
Concentration
10 nM - 10 uM
Shipping Temp
Room Temperature
Molecular Weight
357.8 da
SUPPLIER INFO
Latest promotions
Buy any polyclonal or monoclonal antibody from our extensive range of pre-made antibodies and for a limited time only receive a $50 discount!(T&C apply:...
New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...
We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!
For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...
10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...
Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...
Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...
Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...
Top suppliers
Agrisera AB
11 products
Biotrend
Biosensis
969 products
ABBIOTEC
3011 products
SDIX
1 products
Spring Bioscience
2291 products
Cell Signaling Technology
4976 products
Rockland Immunochemicals, Inc.
7592 products
Boster Immunoleader
1533 products
OriGene Technologies Inc.
5281 products
Maine Biotechnology Services
227 products
BD (Becton, Dickinson and Company)
1 products
ABNOVA CORPORATION
Randox Life Sciences
1502 products
