5'-Iodoresiniferatoxin. A�Potent and Partial Antagonist of the TRPV1.
5�-Iodoresiniferatoxin (5�-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel. It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5�-Iodoresiniferatoxin partially blocked capsaicin induced currents in Xenopus oocytes expressing TRPV1 channels (IC50=3.9 nM). 5�-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on Cav currents (probably mediated by TRPV1) in DRG neurons.
Ion Channel Modulators; TRP Channel Modulators