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TERT Polyclonal Antibody

Cat no: ABP57609

TERT Polyclonal Antibody

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by TERT?telomerase reverse transcriptase), and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

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SPECIFICATIONS

Catalog Number

ABP57609

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IHC-F, WB

Hosts

Rabbit

Reactivities

Hum

Gene Id

7015

Isotype

Rabbit IgG

Accession

O14746

Clonality

Polyclonal

Concentration

1 mg/ml

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