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Stat3 (phospho Ser727) Polyclonal Antibody

Cat no: ABP50406

Stat3 (phospho Ser727) Polyclonal Antibody

Signal transducer and activator of transcription 3 encoded by STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Signal transducer and activator of transcription 3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2.Signal transducer and activator of transcription 3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in STAT3 are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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SPECIFICATIONS

Catalog Number

ABP50406

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Gene Id

6774

Isotype

Rabbit IgG

Accession

P40763

Clonality

Polyclonal

Concentration

1 mg/ml

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