Stat1 (phospho Tyr701) Polyclonal Antibody

Signal transducer and activator of transcription 1 encoded by STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Signal transducer and activator of transcription 1can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. Signal transducer and activator of transcription 1 mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.