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RUNX2 Polyclonal Antibody

Cat no: ABP53087

RUNX2 Polyclonal Antibody

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Runt-related transcription factor 2 is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

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SPECIFICATIONS

Catalog Number

ABP53087

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Gene Id

860

Isotype

Rabbit IgG

Accession

Q13950

Clonality

Polyclonal

Concentration

1 mg/ml

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