PKM encodes a protein involved in glycolysis. Pyruvate kinase, muscleprovided by is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. Pyruvate kinase, muscleprovided by has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. Pyruvate kinase, muscleprovided by has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of pyruvate kinase, muscleprovided by in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported