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phospho-MLKL (S358) Mouse Monoclonal Antibody(6F8)

Cat no: ABM40324

phospho-MLKL (S358) Mouse Monoclonal Antibody(6F8)

MLKL?mixed lineage kinase domain like) belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of MLKL inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for MLKL.

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SPECIFICATIONS

Catalog Number

ABM40324

Size

30micro l, 100micro l, 200micro l

Applications

IF, IHC-F

Hosts

Mouse

Reactivities

Hum

Gene Id

197259

Isotype

Mouse IgG1

Accession

Q8NB16

Clonality

Monoclonal

Concentration

1 mg/ml

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