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N/H/K-Ras Polyclonal Antibody

Cat no: ABP51887

N/H/K-Ras Polyclonal Antibody

HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. GTPase Hras undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

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SPECIFICATIONS

Catalog Number

ABP51887

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IHC-F, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Gene Id

3265/3845/4893

Isotype

Rabbit IgG

Accession

P01111/P01112/P01116

Clonality

Polyclonal

Concentration

1 mg/ml

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