Mouse VPS10 domain-containing receptor SorCS3 (SORCS3) ELISA Kit

SORCS3 encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing.

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SPECIFICATIONS

Catalog Number

KTE70405

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

66673

Accession

Q8VI51

Additional Info

Mouse VPS10 domain-containing receptor SorCS3 (SORCS3) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SORCS3. No significant cross-reactivity or interference between Mouse SORCS3 and analogues was observed.