Mouse Urokinase-type Plasminogen Activator Receptor (PLAUR/uPAR) ELISA Kit

uPAR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. All three domains are necessary for high affinity binding of the primary ligand, urokinase. It has been possible to express uPAR recombinantly in CHO-cells and S2 cells. 4 out of 5 of the possible glycosylation sites are used in vivo giving the protein a molecular weight of 50-60 kDA. Recently the structure of uPAR was solved by X-ray crystallography in complex with an peptide antagonist and with its native ligand, urokinase.However the components of the plasminogen activation system have been found to be highly expressed in many malignant tumors, indicating that tumors are able to hijack the system, and use it in metastasis. Thus inhibitors of the various components of the plasminogen activation system has been sought as possible anticancer drugs.

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SPECIFICATIONS

Catalog Number

KTE70732

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

18793

Accession

P35456

Additional Info

Mouse Urokinase-type Plasminogen Activator Receptor (PLAUR/uPAR) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PLAUR/uPAR. No significant cross-reactivity or interference between Mouse PLAUR/uPAR and analogues was observed.