Mouse Urokinase plasminogen activator (uPA) ELISA Kit

Urokinase-type plasminogen activator is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.

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SPECIFICATIONS

Catalog Number

KTE70733

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

18792

Accession

P06869

Additional Info

Mouse Urokinase plasminogen activator (uPA) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PLAU. No significant cross-reactivity or interference between Mouse PLAU and analogues was observed.