Mouse Transforming growth factor ?2 (TGF-?2) ELISA Kit

Tgfb2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. Tgfb2 encodes multiple isoforms that may undergo similar proteolytic processing.

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SPECIFICATIONS

Catalog Number

KTE70369

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

21808

Accession

P27090

Additional Info

Mouse Transforming growth factor ?2 (TGF-?2) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TGFB2. No significant cross-reactivity or interference between Mouse TGFB2 and analogues was observed.