Mouse Trace amine-associated receptor 2 (TAAR2) ELISA Kit

Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene. TAAR2 is coexpressed with G? proteins; however, as of February 2017, its signal transduction mechanisms have not been determined. Human TAAR2 (hTAAR2) is expressed in the cerebellum, olfactory sensory neurons in the olfactory epithelium, and leukocytes (i.e., white blood cells), among other tissues.[7][8] hTAAR1 and hTAAR2 are both required for white blood cell activation by trace amines in granulocytes.[9] Phenethylamine, para-tyramine, and 3-iodothyronamine are full agonists of hTAAR2 with EC50 values of 0.43 В± 0.05 nM, 0.52 В± 0.05 nM, and 0.25 В± 0.04 nM respectively. A single nucleotide polymorphism nonsense mutation of the TAAR2 gene is associated with schizophrenia. TAAR2 is a probable pseudogene in 10вЂ“15% of Asians as a result of a polymorphism that produces a premature stop codon at amino acid 168.

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SPECIFICATIONS

Catalog Number

KTE70322

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

209512

Accession

Q5QD17

Additional Info

Mouse Trace amine-associated receptor 2 (TAAR2) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TAAR2. No significant cross-reactivity or interference between Mouse TAAR2 and analogues was observed.