Mouse Tolloid-like protein 1 (TLL1) ELISA Kit

TLL1 encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites. As previously demonstrated for BMP1 and TLD, TLL1 specifically processes procollagen C-propeptides at the physiologically relevant site, whereas TLL2 lacks this activity. BMP1 and TLL1 cleave chordin, at sites similar to procollagen C-propeptide cleavage sites, and counteract dorsalizing effects of chordin upon overexpression on Xenopus embryos. Proteases TLD and TLL2 do not cleave chordin.TLL1 gene plays multiple roles in formation of the mammalian heart and is essential for formation of the interventricular septum.

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SPECIFICATIONS

Catalog Number

KTE70215

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

21892

Accession

Q62381

Additional Info

Mouse Tolloid-like protein 1 (TLL1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TLL1. No significant cross-reactivity or interference between Mouse TLL1 and analogues was observed.