Mouse Toll/Interleukin-1 receptor domain-containing adapter protein (TIRAP) ELISA Kit

TIRAP is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. MAL, unlike MYD88, does not interact with IRAK1 and is not inhibited by the dominant-negative N-terminal region of IRAK1; however, like MYD88, MAL does, through its TIR domain, interact with and is inhibited in NFKB activation by the dominant-negative form of IRAK2. A dominant-negative form of MAL inhibits TLR4 or lipopolysaccharide activation of NFKB, but not NFKB activation by IL1R1 or IL18R. Immunoprecipitation analysis showed that TLR4 and MAL are constitutively associated.

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SPECIFICATIONS

Catalog Number

KTE70221

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

117149

Accession

Q99JY1

Additional Info

Mouse Toll/Interleukin-1 receptor domain-containing adapter protein (TIRAP) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TIRAP. No significant cross-reactivity or interference between Mouse TIRAP and analogues was observed.