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Mouse Synaptojanin-1 (SYNJ1) ELISA Kit

Cat no: KTE70292

Mouse Synaptojanin-1 (SYNJ1) ELISA Kit

Synaptojanin-1 is a phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) that has a role in clathrin-coated pit dynamics. The authors found that synaptojanin-170, an alternatively spliced isoform of SYNJ1, binds EPS15 , a clathrin coat-associated protein. Binding was mediated by the C-terminal region of synaptojanin-170, which contains 3 asparagine-proline-phenylalanine (NPF) repeats.\nThis motif had been found to be the core of the binding site for the EH domains of EPS15. These findings suggested that SYNJ1 can be recruited to clathrin-coated pits via a multiplicity of interactions.These Synj1-deficient mice exhibited neurologic defects and died shortly after birth.

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SPECIFICATIONS

Catalog Number

KTE70292

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

Q8CHC4

Additional Info

Mouse Synaptojanin-1 (SYNJ1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SYNJ1. No significant cross-reactivity or interference between Mouse SYNJ1 and analogues was observed.

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