Mouse Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (SDHD) ELISA Kit

SDHD, which stands for succinate dehydrogenase complex subunit D, is one of the two transmembrane subunits of the four-subunit succinate dehydrogenase protein complex that resides in the inner mitochondrial membrane. It also refers to the gene that codes for this protein.\nGermline mutations in SDHD were first linked to hereditary paraganglioma in 2000. Since then, it has been shown that mutations in SDHB and to a lesser degree SDHC can cause paranglioma as well familial pheochromocytoma. Notably, the tumor spectrum is different for the different mutations. SDHB mutations often lead to metastatic disease that is extra-adrenal, while SDHD mutation related tumors are more typically benign, originating in the head and neck.

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SPECIFICATIONS

Catalog Number

KTE70467

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

66925

Accession

Q9CXV1

Additional Info

Mouse Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (SDHD) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SDHD. No significant cross-reactivity or interference between Mouse SDHD and analogues was observed.