Mouse Sphingosine-1-phosphate lyase 1 (SGPL1) ELISA Kit

Sphingosine-1-phosphate (SPP) participates in the proliferative signal transduction pathways of mammalian cells. SPP synthesis is catalyzed by sphingosine kinase, and SPP degradation is catalyzed by SPP lyase (SPL). The first SPL gene cloned, BST1 ('bestowed of sphingosine tolerance'), was isolated from budding yeast . A yeast mutant strain containing a deletion of the entire BST1 coding region is sensitive to the growth-inhibitory effects of D-erythro-sphingosine, due to its inability to degrade SPP. Spl, that has 59% sequence similarity to the BST1 gene product. They showed that this cDNA can functionally complement the yeast BST1 deletion, restoring a sphingosine-resistant phenotype. Northern blot analysis detected Spl expression in several mouse tissues, with the highest level found in the liver.

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SPECIFICATIONS

Catalog Number

KTE70440

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

20397

Accession

Q8R0X7

Additional Info

Mouse Sphingosine-1-phosphate lyase 1 (SGPL1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SGPL1. No significant cross-reactivity or interference between Mouse SGPL1 and analogues was observed.