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Mouse Spectrin alpha chain, brain (SPTAN1) ELISA Kit

Cat no: KTE70249

Mouse Spectrin alpha chain, brain (SPTAN1) ELISA Kit

Alpha-Fodrin is an intracellular, actin-binding, organ-specific protein of the cytoskeleton. The network of actin and fodrin situated below the plasma membrane of secretorial cells, is important for the alignment of secretorial vesicles to the plasma membrane during secretorial processes. During apoptosis the alpha-fodrin dimer is cleaved into a 120 kDa breakdown product, which is found abundantly in the salivary gland. This proteolysis of fodrin may be a consequence of protease activation during apoptosis. The cleavage product of 120 kDa alpha-fodrin was found to be an important autoantigen in the pathogenesis of organ-specific autoimmune esponse. Clinical studies have shown, that in patients with SjГ¶gren Syndrome alpha-fodrin is involved in the stimulation of peripheral blood T-cells.

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SPECIFICATIONS

Catalog Number

KTE70249

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

P16546

Additional Info

Mouse Spectrin alpha chain, brain (SPTAN1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SPTAN1. No significant cross-reactivity or interference between Mouse SPTAN1 and analogues was observed.

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SUPPLIER INFO

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