Mouse Soluble Toll-like Receptor 4 (sTLR4) ELISA Kit

Tlr4 belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by Tlr4 mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in Tlr4 display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls.

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SPECIFICATIONS

Catalog Number

KTE70210

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

21898

Accession

Q9QUK6

Additional Info

Mouse Soluble Toll-like Receptor 4 (sTLR4) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TLR4. No significant cross-reactivity or interference between Mouse TLR4 and analogues was observed.