Mouse Serine/threonine-protein kinase PLK1 (PLK1) ELISA Kit

Plk1 consists of 603 amino acids and is 66kDa. In addition to the N-terminus kinase domain, there are two conserved polo-box regions of 30 amino acids at the C-terminus.\nPlk1 is an early trigger for G2/M transition. Plk1 supports the functional maturation of the centrosome in late G2/early prophase and establishment of the bipolar spindle. Plk1 phosphorylates and activates cdc25C, a phosphatase that dephosphorylates and activates the cyclinB/cdc2 complex. Plk phosphorylates and activates components of the APC. The APC, which is activated by Fizzy-Cdc20 family proteins, is a cell cycle ubiquitin-protein ligase (E3) that degrades mitotic cyclins, chromosomal proteins that maintain cohesion of sister chromatids, and anaphase inhibitors.

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SPECIFICATIONS

Catalog Number

KTE70729

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

18817

Accession

Q07832

Additional Info

Mouse Serine/threonine-protein kinase PLK1 (PLK1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PLK1. No significant cross-reactivity or interference between Mouse PLK1 and analogues was observed.