Mouse Serine/threonine-protein kinase DCLK1 (DCLK1) ELISA Kit

Doublecortin-like kinase 1 (Dclk1)В В encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

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SPECIFICATIONS

Catalog Number

KTE71328

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

13175

Accession

Q9JLM8

Additional Info

Mouse Serine/threonine-protein kinase DCLK1 (DCLK1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse DCLK1. No significant cross-reactivity or interference between Mouse DCLK1 and analogues was observed.