Mouse Serine/threonine-protein kinase 11 (STK11) ELISA Kit

LKB1 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It is now clear that LKB1 exerts its growth suppressing effects by activating a group of other ~14 kinases, comprising AMPK and AMPK-related kinases. Activation of AMPK by LKB1 suppresses growth and proliferation when energy and nutrient levels are scarce. Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions.

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SPECIFICATIONS

Catalog Number

KTE70269

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

20869

Accession

Q9WTK7

Additional Info

Mouse Serine/threonine-protein kinase 11 (STK11) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse STK11. No significant cross-reactivity or interference between Mouse STK11 and analogues was observed.