Mouse Serine palmitoyltransferase 3 (SPTLC3) ELISA Kit

SPTLC3 orthologs were found in rat, mouse, and dog. Quantitative real-time PCR of human tissues showed highest expression in placenta, followed by skin, adrenal gland, testis, uterus, salivary gland, prostate, and kidney, lower expression in all other tissues, and no expression in peripheral blood cells and bone marrow. SPTLC3 and SPTLC2 showed different expression patterns, possibly reflecting tissue-specific requirements of sphingolipid synthesis. Western blot analysis revealed SPTLC3 expression in human trophoblast cell lines. Overexpression of SPTLC3 in HEK293 cells, which have little endogenous SPTLC3, resulted in increased SPT activity by 2- to 3-fold. Expression of an SPTLC3-specific siRNA in HepG2 cells and human trophoblast cells significantly decreased SPT activity, indicating that SPTLC3 plays a role in SPT activity.

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SPECIFICATIONS

Catalog Number

KTE70252

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

228677

Accession

Q8BG54

Additional Info

Mouse Serine palmitoyltransferase 3 (SPTLC3) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SPTLC3. No significant cross-reactivity or interference between Mouse SPTLC3 and analogues was observed.