Mouse RILP-like protein 2 (RILPL2) ELISA Kit

RILPL2 regulates cellular morphology. Knockdown of endogenous RILPL2 in neurons by short hairpin RNA (shRNA) interference results in reduced spine-like protrusions, a phenotype rescued by overexpression of an shRNA-insensitive RILPL2 mutant, suggesting a role for RILPL2 in both the establishment and maintenance of dendritic spines. RILPL2 and the Rho GTPase Rac1 form a complex, and that RILPL2 is able to induce activation of Rac1 and its target, p21-activated kinase (Pak). Notably, both RILPL2-mediated morphological changes and activation of Rac1-Pak signaling were blocked by expression of a truncated tail form of MyoVa or MyoVa shRNA, demonstrating that MyoVa is crucial for proper RILPL2 function. This might represent a novel mechanism linking RILPL2, the motor protein MyoVa and Rac1 with neuronal structure and function

Prices direct from Abbkine Scientific Co.Ltd.

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

KTE70501

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

80291

Accession

Q99LE1

Additional Info

Mouse RILP-like protein 2 (RILPL2) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse RILPL2. No significant cross-reactivity or interference between Mouse RILPL2 and analogues was observed.