Mouse Replication initiator 1 (REPIN1) ELISA Kit

Replication initiator 1 is a protein encoded by the REPIN1 gene. Homodimers of RIP60 (replication initiation-region protein 60 kDA) purified from nuclear extract bind two ATT-rich sites in oribeta and foster the formation of a twisted 720 bp DNA loop in vitro.\nRIP60 contains 15 C(2)H(2)zinc finger (ZF) DNA binding motifs organized in three clusters, termed hand Z1 (ZFs 1-5), hand Z2 (ZFs 6-8) and hand Z3 (ZFs 9-15). A proline-rich region is located between hands Z2 and Z3. Gel mobility shift and DNase I footprinting experiments show hands Z1 and Z2 independently bind the oribeta RIP60 sites specifically, but with different affinities. Hand Z3 binds DNA, but displays no specificity for RIP60 sites.

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SPECIFICATIONS

Catalog Number

KTE70507

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

58887

Accession

Q5U4E2

Additional Info

Mouse Replication initiator 1 (REPIN1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse REPIN1. No significant cross-reactivity or interference between Mouse REPIN1 and analogues was observed.