Mouse Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) ELISA Kit

PRDM6, is enriched in flk1(+) hematovascular precursor cells using a microarray-based approach. PRDM6 is also detected in embryonic and adult-derived endothelial cell lines. PRDM6 is co-localized with histone H4 and methylates H4-K20 (but not H3) in vitro and in vivo. Overexpression of PRDM6 in mouse embryonic endothelial cells induces apoptosis by activating caspase-3 and inducing G1 arrest. PRDM6 inhibits cell proliferation as determined by BrdU incorporation in endothelial cells, but not in rat aortic smooth muscle cells. PRDM6 is expressed by vascular precursors, has differential effects in endothelial cells and smooth muscle cells, and may play a role in vascular precursor differentiation and survival by modulating local chromatin-remodeling activity within hematovascular subpopulations during development.

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SPECIFICATIONS

Catalog Number

KTE70697

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

225518

Accession

Q3UZD5

Additional Info

Mouse Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PRDM6. No significant cross-reactivity or interference between Mouse PRDM6 and analogues was observed.