Mouse Protection of telomeres protein 1 (POT1) ELISA Kit

POT1 is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.Human POT1 encodes a 71-kD protein whose N-terminal region shares 26% identity with the N terminus of S. pombe Pot1. POT1 is a housekeeping gene required to ensure the integrity of chromosome ends in all cells.

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SPECIFICATIONS

Catalog Number

KTE70711

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

101185

Accession

Q91WC1

Additional Info

Mouse Protection of telomeres protein 1 (POT1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse POT1. No significant cross-reactivity or interference between Mouse POT1 and analogues was observed.