Mouse Prostacycline (PGI2) ELISA Kit

Prostacyclin is produced in endothelial cells from prostaglandin H2 (PGH2) by the action of the enzyme prostacyclin synthase. Although prostacyclin is considered an independent mediator, it is called PGI2 in eicosanoid nomenclature, and is a member of the prostanoids.The series-3 prostaglandin PGH3 also follows the prostacyclin synthase pathway, yielding another prostacyclin, PGI3. The unqualified term 'prostacyclin' usually refers to PGI2. PGI2 is derived from the ?-6 arachidonic acid. PGI3 is derived from the ?-3 EPA. Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It does this by inhibiting platelet activation. It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage.

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SPECIFICATIONS

Catalog Number

KTE70763

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Additional Info

Mouse Prostacycline (PGI2) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PGI2. No significant cross-reactivity or interference between Mouse PGI2 and analogues was observed.