Mouse Prolyl endopeptidase (PREP) ELISA Kit

Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the PREP gene.Prolyl endopeptidase is a large cytosolic enzyme that belongs to a distinct class of serine peptidases. It was first described in the cytosol of rabbit brain as an oligopeptidase, which degrades the nonapeptide bradykinin at the Pro-Phe bond.[5] The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotensin, neurotensin, oxytocin, substance P and vasopressin. PREP cleaves peptide bonds at the C-terminal side of proline residues. Its activity is confined to action on oligopeptides of less than 10 kD and it has an absolute requirement for the trans-configuration of the peptide bond preceding proline.\n\nProlyl endopeptidases are involved in the maturation and degradation of peptide hormones and neuropeptides.

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SPECIFICATIONS

Catalog Number

KTE70687

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

19072

Accession

Q9QUR6

Additional Info

Mouse Prolyl endopeptidase (PREP) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PREP. No significant cross-reactivity or interference between Mouse PREP and analogues was observed.