Mouse Prickle-like protein 1 (PRICKLE1) ELISA Kit

PRICKLE1 encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. The deduced 831-amino acid protein contains 3 N-terminal LIM domains and 3 C-terminal nuclear localization signals. It also contains 4 N-glycosylation sites, 2 PKA phosphorylation sites, and a C-terminal CIIS (cys-ile-ile-ser) prenylation motif. Northern blot analysis detected a single 4.4-kb transcript in all tissues examined, with the highest level in placenta.

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SPECIFICATIONS

Catalog Number

KTE70680

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

106042

Accession

Q3U5C7

Additional Info

Mouse Prickle-like protein 1 (PRICKLE1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PRICKLE1. No significant cross-reactivity or interference between Mouse PRICKLE1 and analogues was observed.