Mouse Pregnancy associated plasma protein A (PAPP-A) ELISA Kit

PAPP-A is a large heterottetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of DownвЂ™s syndrome. a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome.

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SPECIFICATIONS

Catalog Number

KTE70790

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

18491

Accession

Q8R4K8

Additional Info

Mouse Pregnancy associated plasma protein A (PAPP-A) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PAPP-A. No significant cross-reactivity or interference between Mouse PAPP-A and analogues was observed.