Mouse POU domain, class 5, transcription factor 1 (POU5F1) ELISA Kit

Oct-4 is a homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will actually cause differentiation of the cells.\nOct-4 transcription factor is initially active as a maternal factor in the oocyte but remains active in embryos throughout the preimplantation period. Oct-4 expression is associated with an undifferentiated phenotype and tumors. In fact gene knockdown of Oct-4 promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal.

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SPECIFICATIONS

Catalog Number

KTE70710

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

18999

Accession

P20263

Additional Info

Mouse POU domain, class 5, transcription factor 1 (POU5F1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse POU5F1. No significant cross-reactivity or interference between Mouse POU5F1 and analogues was observed.