Mouse Platelet Factor 4 (PF-4) ELISA Kit

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family. This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. PF4 autoantibodies have also been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.

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SPECIFICATIONS

Catalog Number

KTE70770

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

56744

Accession

Q9Z126

Additional Info

Mouse Platelet Factor 4 (PF-4) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PF-4. No significant cross-reactivity or interference between Mouse PF-4 and analogues was observed.