Mouse Parathyroid Hormone Related Protein (PTHRP) ELISA Kit

Parathyroid hormone-related protein (or PTHrP) is a protein occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell carcinoma). However, it also has normal functions.\nPTHrP acts as an endocrine, autocrine/ paracrine, and intracrine hormone. PTHrP is related in function to the "normal" parathyroid hormone. When a tumor secretes PTHrP, this can lead to hypercalcemia. As this is sometimes the first sign of the malignancy, hypercalcemia caused by PTHrP is considered a paraneoplastic phenomenon. PTHrP shares the same N-terminal end as parathyroid hormone and therefore it can bind to the same receptor (the Type I PTH receptor). PTHrP aids in normal mammary gland development and lactation as well as placental transfer of calcium.

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SPECIFICATIONS

Catalog Number

KTE70620

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

P22858

Additional Info

Mouse Parathyroid Hormone Related Protein (PTHRP) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse PTHRP. No significant cross-reactivity or interference between Mouse PTHRP and analogues was observed.