Mouse NAD-dependent deacetylase sirtuin-1 (Sirt1) ELISA Kit

Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.\nSirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.

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SPECIFICATIONS

Catalog Number

KTE70437

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

93759

Accession

Q923E4

Additional Info

Mouse NAD-dependent deacetylase sirtuin-1 (Sirt1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SIRT1. No significant cross-reactivity or interference between Mouse SIRT1 and analogues was observed.