Mouse Myelin transcription factor 1-like protein (MYT1L) ELISA Kit

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.

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SPECIFICATIONS

Catalog Number

KTE70849

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

P97500

Additional Info

Mouse Myelin transcription factor 1-like protein (MYT1L) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse MYT1L. No significant cross-reactivity or interference between Mouse MYT1L and analogues was observed.