Mouse Myelin protein zero-like protein 2 (MPZL2) ELISA Kit

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. Myelin protein zero-like protein 2 (MPZL2) is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. MPZL2 bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for MPZL2.

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SPECIFICATIONS

Catalog Number

KTE70959

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Accession

O70255

Additional Info

Mouse Myelin protein zero-like protein 2 (MPZL2) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse MPZL2. No significant cross-reactivity or interference between Mouse MPZL2 and analogues was observed.