Mouse Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) ELISA Kit

TIM44, a peripheral inner membrane protein, tethers mitochondrial HSP70 to the import channel. A model peptide substrate rapidly released mitochondrial HSP70 from TIM44, even in the absence of ATP hydrolysis. In vivo, the analogous interaction of translocating polypeptide would release mitochondrial HSP70 from the channel.\nTIMM44 is hydrophilic and contains no hydrophobic membrane-spanning segments. The N terminus has a coiled-coil motif and a matrix-targeting segment with 6 positively and no negatively charged residues. Western blot analysis showed that TIMM44 is present in membranes as well as matrix and is most likely a 45-kD peripheral membrane protein loosely associated with the inner membrane of mitochondria.

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SPECIFICATIONS

Catalog Number

KTE70228

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

21856

Accession

O35857

Additional Info

Mouse Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse TIMM44. No significant cross-reactivity or interference between Mouse TIMM44 and analogues was observed.