Mouse Midline-1 (MID1) ELISA Kit

The protein encoded by MID1 is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in MID1 have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. MID1 was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities.

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SPECIFICATIONS

Catalog Number

KTE71030

Size

48T, 96T, 96T*5, 96T*50

Applications

ELISA

Reactivities

Mouse

Gene Id

17318

Accession

O70583

Additional Info

Mouse Midline-1 (MID1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse MID1. No significant cross-reactivity or interference between Mouse MID1 and analogues was observed.