Mouse Mediator of DNA damage checkpoint protein 1 (MDC1) ELISA Kit

The protein encoded by Mdc1 contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 7 divergent copies of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Mice with mutations in Mdc1 exhibit growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivity.